lisa fucking stop posting like tihis while you are mooching off my sweet avatar and user profile
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lisa fucking stop posting like tihis while you are mooching off my sweet avatar and user profile
Go eat rooty's dried up semen off your carpet
too much dense of dunning-kruger effectQuote:
Originally Posted by Dirty Beatle
lisa you crazy biitch knock this off
yeah yeah yeah we all know i'm the smartest most intellectually-inclined one here, it's okay though, there are plenty of tards out there livin really kick ass lives
It's aioli and I already cleaned it. See the bottle was getting empty and was not coming out so I swung it to get all the aioli to the top near the nozzle but the lid flipped open and aioli spurted everywhere.Quote:
Originally Posted by Jihad Josh
At least that's my story and I'm sticking to it.
this thread just got what plants crave
you know I am smarter than you.Quote:
Originally Posted by Plug Drugs
You need to stop this challenge to my intellectual superiority before I destroy you easily.
The sunshine out of my ass. Yes.Quote:
Originally Posted by Autistic Spectrum
electrolytes
if that's true why do you have the shittiest lifeQuote:
Originally Posted by Plug Drugs
I'm the smartest squirrel guys but I starved to death because I just couldn't wrap my head around finding acorns
Quote:
Originally Posted by Jihad Josh
Quote:
Originally Posted by Jihad Josh
That's so cute.Quote:
Originally Posted by maks
Quote:
Originally Posted by cbarry
You have to admit that plug drugs isn't starving
ouch
i was a year and a half ago when i was living in a shithole
for dinner we had rice, and it was good
Calsyntenin-1 Affects Trafficking of
NMDA Receptor Subunits
Jeanne Ster, Martin Steuble, Clara Orlando,
Tu-My Diep, Alexander Akhmedov, et al.
(see pages 8716–8727)
Membrane proteins are transported in vesicles
that are carried along microtubules by
motor proteins. Motors interact with vesicles
by binding to adaptor proteins such as
calsyntenin-1, which couples vesicles to
kinesin-1 and is associated with early and
recycling endosomes. Previous studies suggested
a role for calsyntenins in synaptic
plasticity, prompting Ster et al. to examine
the effects of truncating calsyntenin-1 in
mice to prevent its interaction with kinesin.
In the hippocampus of juvenile mutant
mice, the frequency and slope of spontaneous
EPSPs were reduced compared to those
in controls, while long-term potentiation
was enhanced. These effects were attributable
to an increase in the synaptic levels of
NMDA receptor GluN2B subunits at the
expense of GluN2A subunits. GluN2A,
GluN2B, and GluN1 subunits all colocalized
with calsyntenin-1 in endosomes, suggesting
the trafficking of all three subunits
involves calsyntenin-1. However, the timing
of calsyntenin-1 expression and the effects
of the mutation suggest that calsyntenin-1 is
especially important for the postnatal increase
in GluN2A expression.
no you were not starvingQuote:
Originally Posted by Plug Drugs
how the fuck are you going to say that? were you there? you're a shallow fucking cunt who thinks she can deduce everything about a person
she's mentally retarded give her a break
she's right starving people don't weigh 350lbs and scarf entire pizzas every night on camQuote:
Originally Posted by Plug Drugs
a year and a half ago i was living in a dilapidated shithole working for minimum wage and living off rice and oatmeal that my roommates relatives brought over in a box once a month in what we called "poverty packages"Quote:
Originally Posted by maks
think whatever you want to you fucking cunt, you dont need to type a response it'll just be more bullshit about me and more of your rude assumptions about me, save it bitch
and yet somehow you were fat as fuck, if you check the wikipedia article about starving you'll find that starving people are not fat as fuck in fact it's quite the oppositeQuote:
Originally Posted by Plug Drugs
this is what starvation looks like, please note that this boy does not have a set of tits because he is starving and not eating enough to build massive fat reserves
http://i.dailymail.co.uk/i/pix/2011/...85_468x366.jpg
Fuck off fatsoQuote:
Originally Posted by Plug Drugs
You are the most ignorant dumb fuck here.