Swallow Whole, Do Not Crush or Chew

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Originally Posted by blumpkin blownuts

oxycodone undergoes hepatic metab primarily into oxymorphone, both drugs are pharmacologically active

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theres a shitload dude
just going to copy paste wikipedia, i dont even pretend to memorize these

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Oxycodone is metabolized to α and β oxycodol; oxymorphone, then α and β oxymorphol and noroxymorphone; and noroxycodone, then α and β noroxycodol and noroxymorphone (N-desmethyloxycodone).[3] (14-Hydroxydihydrocodeine that in turn becomes 14-Hydroxydihydromorphine) These metabolites are true only for humans.[23] As many as six metabolites for oxycodone (14-hydroxydihydromorphinone, 14-hydroxydihydrocodeine, 14-hydroxydihydrocodeinone N-oxide {oxycodone N-oxide}, 14-hydroxydihydroisocodeine, 14-hydroxydihydrocodeine N-oxide, and noroxycodone) have been found in rabbits,[24] several of which are thought to be active metabolites to some extent, although a study using conventional oral oxycodone concluded oxycodone itself, and not its metabolites, is predominantly responsible for the drug's opioid effects on the brain.[3]

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Originally Posted by Plug Drugs

theres a shitload dude
just going to copy paste wikipedia, i dont even pretend to memorize these

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kiss me passionatly. i'm drunk

if you want my two cents i'd say the oxycodone molecule itself is only responsible for 30-40% of pharmacological effects, and that's cut in half after the first 3 hours (oc's half life is like 3-4 hours). For me, I'm still peaking at the 3 hour mark, which, just to me, suggests that the metabolites, and not oxycodone itself, are primarily responsible for its effects.
As always, everyone is different, especially when it comes to drugs with active metabolites, as people's hepatic activity varies drastically between individuals

i don't understand why you're not on the dole, bro

i'm a huge fag, monde.

i'm serious about this he would do so well. he obviously needs it much more than steveyos.

get on my dole

this has nothing to do with rep, rootbeer

i had debillitating growing pains when i was 13-14, like the "you dont know pain until youve experienced something like that" kind, know what they gave me? fucking tylenol 3s w/ codeine.. When i broke my femur, largest bone in the human body, they gave me one 30 count bottle of 5mg lortabs, fuckin shit they give out for tootheaches. How do i get the good shit? Do i have to be a hot blonde with big boobs or upper middle class before doctors start sucking my proverbial cock with strong mu-opioid agonists?? Am i going to be laying on my death bed with my organs laying out all over the place, and the docs saying "uhhh here, have some aspirin"?

And then last summer, the night before my grandfather died and he was choking to death on his own saliva due to a giant hole cancer ate away in his esophagus, having to ARGUE with the night nurse to give him morphine or fucking ANYTHING, I have a justifiable VENDETTA against the god damn medical system; i won't be satisfied until there's doctors out on the fucking streets holding up cardboard signs saying "Will Diagnosis You With RLS For Food"

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Originally Posted by Plug Drugs

i had debillitating growing pains when i was 13-14, like the "you dont know pain until youve experienced something like that" kind, know what they gave me? fucking tylenol 3s w/ codeine.. When i broke my femur, largest bone in the human body, they gave me one 30 count bottle of 5mg lortabs, fuckin shit they give out for tootheaches. How do i get the good shit? Do i have to be a hot blonde with big boobs or upper middle class before doctors start sucking my proverbial cock with strong mu-agonists?? Am i going to be laying on my death bed with my organs laying out all over the place, and the docs saying "uhhh here, have some aspirin"?

And then last summer, the night before my grandfather died and he was choking to death on his own saliva due to a giant hole cancer ate away in his esophagus, having to ARGUE with the night nurse to give him morphine or fucking ANYTHING, I have a justifiable VENDETTA against the god damn medical system; i won't be satisfied until there's doctors out on the fucking streets holding up cardboard signs saying "Will Diagnosis You With RLS For Food"

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ya, you need welfare, bro
go steal some of steffies' medical marijuana

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Originally Posted by Plug Drugs

80mg is fucking childs play :rofl: i was up to like 210 doses multiple times a day til and would get to the point where i was falling asleep standing up

The problem with oxycodone is that its largely a prodrug and metabolizes into different opioids in vivo, all of which have different half-lives.. So while the shorter half-life metabolites wear off, the long half-life ones are building up in your system with each subsequent dose.. so its really easy to end up taking more and more doses until you end up getting to the point where not even slapping yourself to stay awake works, then you have to worry about puking in your sleep, pulmonary edema, all sorts of goodies. You can get to the point where half a beer or taking half a dose of an allergy medication will kill you

when a hit brings you an inch away from death, thats livin man

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youre going to die, i hope you have naloxone

210 doses jesus fucking christ lmfao

how is it this guy isn't on welfare?
guy, go to fjs RIGHT NOW!

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Originally Posted by Plug Drugs

i had debillitating growing pains when i was 13-14, like the "you dont know pain until youve experienced something like that" kind, know what they gave me? fucking tylenol 3s w/ codeine.. When i broke my femur, largest bone in the human body, they gave me one 30 count bottle of 5mg lortabs, fuckin shit they give out for tootheaches. How do i get the good shit? Do i have to be a hot blonde with big boobs or upper middle class before doctors start sucking my proverbial cock with strong mu-opioid agonists?? Am i going to be laying on my death bed with my organs laying out all over the place, and the docs saying "uhhh here, have some aspirin"?

And then last summer, the night before my grandfather died and he was choking to death on his own saliva due to a giant hole cancer ate away in his esophagus, having to ARGUE with the night nurse to give him morphine or fucking ANYTHING, I have a justifiable VENDETTA against the god damn medical system; i won't be satisfied until there's doctors out on the fucking streets holding up cardboard signs saying "Will Diagnosis You With RLS For Food"

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no you dont, youre the reason the medical system is hesitant to hand out morphine to people who ask for it you stupid fuck. pain management specialists all over the world have to deal with your fecal matter oozing down and staining their otherwise very important profession

a dose of 210 or 210 doses? no one knows for sure, not even me

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Originally Posted by Gentleman Doli

no you dont, youre the reason the medical system is hesitant to hand out morphine to people who ask for it you stupid fuck. pain management specialists all over the world have to deal with your fecal matter oozing down and staining their otherwise very important profession

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ive never asked for painkillers, the only time i went to the doctor for PAIN was when i was 13 and had growing pains in my back. the only other time in my life a doctor has prescribed me painkillers was when i was 16 and broke my femur and i got the one bottle of thirty 5mg/500mg hydroco/apap pills (a single fucking bottle mind you, try stretching that fucker out over the 2 months you're bed-ridden with a broken femur)

ive gone to the doctor before seeking benzos, but thats because i was getting panic attacks like multiple times a day non stop for a few years, and i didnt want to have to be on a daily ssri or tca every fucking day so, yes, i tried fishing for a fuckin PRN script of a benzo when i was a teenager, because doctors are so fucking paranoid to hand them out, that someone who actually needs one has to fake illness just to get it

go to a psychiatrist seeking a diagnosis and then get on welfare so you don't have to work at walmart with doli

fagg

PRN scripts to benzos dont turn people into physical addicts btw, its when the pharmaceutical company tells docs "ooop, dont want to do that, because then they might take it more than prescribed or misuse it! they should be on it DAILY MWAHAHAHAHA" that forces anxiety-related illness patients to become addicts, because they've got a drug that is well known for causing physical dependence in their system 24/7 because the doctor was too scared just to give 10 of the little fuckin things to them once a month that they could take as needed.
The Pharmaceutical Industry Wants Addicts doli, and you're one of their mindless footsoldiers oblivious to whats going on higher up

gerh5r4j4skkj

plug drugs only posts when he is high out of his mind i think

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Originally Posted by Plug Drugs

its all a scheme to beat down minorities and undesirables into poverty and a legal war they cant win, so we can assert our position as the Great White Cock, the phallus which shall rule supreme over all others

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Originally Posted by Plug Drugs

because they're recreational drug seekers too, just ones deemed acceptable by society

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you should tell that to the dozen or so soccer-moms-turned-gutter-whores in my NA group who switched to heroin when their doctors finally cut them off and they get off the city bus with nothing except their black babbys fathered by those poor beaten down smack peddling minorities

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Originally Posted by blumpkin blownuts

you should tell that to the dozen or so soccer-moms-turned-gutter-whores in my NA group who switched to heroin when their doctors finally cut them off and they get off the city bus with nothing except their black babbys fathered by those poor beaten down smack peddling minorities

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i'm sure it was all the drugs' fault

behind every soccer mom is a stash of benzos, alcohol, or painkillers -- anything to help them cope with the fact that their life is a giant charade of pompous pious pissy bullshittery; that they're a fraud and they know it

plug drugs get a grip man

theres a whole subsection of books at every department store dedicated to this generation of adult women who secretly hate everyone and everything. Trashy romance, self help books, chicken soup for the used-up, benzoed-out "married to a fat snub-dicked dick-head's" soul

there's no way around it -- many good medicines have side effects, one of those being obsessive compulsions to misuse the medicine in certain types of patients.

the AMA has many times gotten bad medicine taken off the market, no matter how hard the pushers lobby for it. remember palladone? what about rx heroin?

addicts are addicts before they ever pick up the first drug. it's when that happens that the addiction actively manifests itself, and active addiction is the only way to differentiate between the two. like most side effects, it affects a mniority of patients. in the meantime, millions of non-addicts are able to function without debilitating pain.

i look forward to gardening and baking cookies, therefore i am holier than thou

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Originally Posted by Plug Drugs

behind every soccer mom is a stash of benzos, alcohol, or painkillers -- anything to help them cope with the fact that their life is a giant charade of pompous pious pissy bullshittery; that they're a fraud and they know it

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my mom was a soccer mom for awhile and the most she ever needed to cope is lexapro

the vast majority of people who take opiods safely and responsibly dont develop addictions. there are treatments available for those who do. opiods are safe and effective drugs for most people