deaths from drug use (excluding alcohol, nicotine, and medical malpractice) are a fraction of a fraction of a fraction of the total number of deaths each year..

The average number of central nervous system depressants in the system of someone who died from opiate overdose is 2.7; it is highly improbable to overdose on opiates themselves. We're talking about major fuck-ups or intentional suicide; i.e., shooting a bag of H that had fentanyl analogues in it for increased effect; H spiked with some other garbage CNS depressants for potentiation, etc..