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    #1
    I am postulate one blumpkin blownuts's Avatar
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    Quote Originally Posted by Plug Drugs View Post
    80mg is fucking childs play i was up to like 210 doses multiple times a day til and would get to the point where i was falling asleep standing up

    The problem with oxycodone is that its largely a prodrug and metabolizes into different opioids in vivo, all of which have different half-lives.. So while the shorter half-life metabolites wear off, the long half-life ones are building up in your system with each subsequent dose.. so its really easy to end up taking more and more doses until you end up getting to the point where not even slapping yourself to stay awake works, then you have to worry about puking in your sleep, pulmonary edema, all sorts of goodies. You can get to the point where half a beer or taking half a dose of an allergy medication will kill you

    when a hit brings you an inch away from death, thats livin man
    oxycodone undergoes hepatic metab primarily into oxymorphone, both drugs are pharmacologically active
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    Pariah :Care:y Plug Drugs's Avatar
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    Quote Originally Posted by blumpkin blownuts View Post
    oxycodone undergoes hepatic metab primarily into oxymorphone, both drugs are pharmacologically active
    theres a shitload dude
    just going to copy paste wikipedia, i dont even pretend to memorize these
    Oxycodone is metabolized to α and β oxycodol; oxymorphone, then α and β oxymorphol and noroxymorphone; and noroxycodone, then α and β noroxycodol and noroxymorphone (N-desmethyloxycodone).[3] (14-Hydroxydihydrocodeine that in turn becomes 14-Hydroxydihydromorphine) These metabolites are true only for humans.[23] As many as six metabolites for oxycodone (14-hydroxydihydromorphinone, 14-hydroxydihydrocodeine, 14-hydroxydihydrocodeinone N-oxide {oxycodone N-oxide}, 14-hydroxydihydroisocodeine, 14-hydroxydihydrocodeine N-oxide, and noroxycodone) have been found in rabbits,[24] several of which are thought to be active metabolites to some extent, although a study using conventional oral oxycodone concluded oxycodone itself, and not its metabolites, is predominantly responsible for the drug's opioid effects on the brain.[3]
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    #3
    v me in love v Camoron's Avatar
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    Quote Originally Posted by Plug Drugs View Post
    theres a shitload dude
    just going to copy paste wikipedia, i dont even pretend to memorize these
    kiss me passionatly. i'm drunk
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