Quote Originally Posted by Ghost of Plug Drugs View Post
can someone please tell me why microsoft paint fucking sucks, i had this great idea for an avatar for this gimmick (just invert the colors of my old avatar) but ms paint's "invert selection" isnt fucking doing anything god fucking christ didnt you used to just be able to click ctrl + i? Why the fuck did microsoft get rid of file, edit, tools, etc in MS Paint? Are they fucking retarded god i fucking hate everything fuck the world
Long-term use of high doses of Tramadol may be associated with physical dependence and a withdrawal syndrome.[36] Tramadol causes typical opiate-like withdrawal symptoms as well as atypical withdrawal symptoms including seizures[citation needed]. The atypical withdrawal symptoms are probably related to tramadol's effect on serotonin and norepinephrine re-uptake. Symptoms may include those of SSRI discontinuation syndrome, such as anxiety, depression, anguish, severe mood swings, aggressiveness, brain "zaps", electric-shock-like sensations throughout the body, paresthesias, sweating, palpitations, restless legs syndrome, sneezing, insomnia, vivid dreams or nightmares, micropsia and/or macropsia, tremors, and headache among others. In most cases, tramadol withdrawal will set in 12–20 hours after the last dose, but this can vary. Tramadol withdrawal lasts longer than that of other opioids; seven days or more of acute withdrawal symptoms can occur as opposed to typically three or four days for other codeine analogues. It is recommended that patients physically dependent on pain killers take their medication regularly to prevent onset of withdrawal symptoms and this is particularly relevant to tramadol because of its SSRI and SNRI properties, and, when the time comes to discontinue their tramadol, to do so gradually over a period of time that will vary according to the individual patient and dose and length of time on the drug.[37][38][39][40]