in the simplest terms we can put it, drugs change your state of mind. 'Those' who relied on keeping you doubtful and insecure in order to make themselves look good can't keep doing that if all of a sudden your coming at them from the side in a way thats completely unanticipated - random - drug induced.

Giving more credit to the drug user, we could say that the changing of your state of mind allows you to look at things from a new perspective, and re-evaluate your old perspective - giving the drug user metacognition - or "thinking about thinking". They give themselves a third leg in a sense, and a little more stability in how they view the world around them. The flip side obviously being intoxication; chaos; unpredictability; confusion.