not to mention the amount of alcohol in everclear is chemically signifcant, such that it can be reactive with various medicines and bodily tissues on contact -- it can, in vivo, turn methylphenidate into the much more potent "ethylphenidate", within the stomach and intestines. It can also increase the oral bioavailability of things like oxymorphone tenfold - literally turning your standard dose into a lethal dose.

Just imagine the physiological changes it induces on your body even in the absence of other drugs.

Everclear is something I personally as a drug user, don't like to mess around with.