Swallow Whole, Do Not Crush or Chew

[Plug Drugs]

people who stack depressants like that are just flirting with death

[Genital Doli]

people who stack depressants like that are just flirting with death

and you arent mr. 210 doses of oxy a day

[Plug Drugs]

and you arent mr. 210 doses of oxy a day

it is very very difficult to overdose on just an opiate itself (excluding the synthetics like methadone, which sometimes can end up just killing a person for no real reason at all - NMDA antagonism might have something to do with methadone's high toxicity)

it is very very difficult to overdose on just an opiate itself

[Plug Drugs]

how CNS depressants kill you during an overdose is by lowering your respiratory rate down to the point that it simply stops -- and this means you also have to be unconscious (i.e., have fallen asleep or passed out).
A single CNS depressant by itself will not do this typically, because the rest of the neurological pathways in your brain not affected by the drug will still be functioning enough to keep up respiratory rate. However, when CNS depressants are mixed (more than one type of CNS depressant is taken), more areas of the brain have their activity inhibited, and the level of sedation compounds.

i would pop a gram of oxycodone right in front of you with confidence that it wouldn't kill me. Although, it would give me a very very bad time, and i'd likely be unconscious within 10 minutes and be shaking/twitching, perhaps even convulsing - I would still live through it.

So long as its only one CNS depressant in your system, the rule of thumb is that you'll be fine.

A major risk is that there are many over the counter medications, herbs, supplements, and thousands of other things which act as CNS depressants, and can kill a person when they're on an already high dose of a CNS depressant.
Some of these lesser known CNS depressants include things like valerian root in certain kinds of tea, allergy medications (anti-histamines), motion sickness pills (such as dramamine/dimenhydrinate, which is also an antihistamine), blood pressure medications (propranolol, a beta-blocker), and even anti-depressants and anxiolytics like zoloft, effexor, paxil, lexapro, yadda yadda yadda have affinity as an H-1 antagonist and cause sedations.

That's how a lot of celebrities die; they get prescribed so much shit and none of their doctors are really keeping an eye on it, and before they know it they've got 7-8 CNS depressants in their system, have a couple drinks, then pass out and die

[Genital Doli]

how CNS depressants kill you during an overdose is by lowering your respiratory rate down to the point that it simply stops -- and this means you also have to be unconscious (i.e., have fallen asleep or passed out).
A single CNS depressant by itself will not do this typically, because the rest of the neurological pathways in your brain not affected by the drug will still be functioning enough to keep up respiratory rate. However, when CNS depressants are mixed (more than one type of CNS depressant is taken), more areas of the brain have their activity inhibited, and the level of sedation compounds.

i would pop a gram of oxycodone right in front of you with confidence that it wouldn't kill me. Although, it would give me a very very bad time, and i'd likely be unconscious within 10 minutes and be shaking/twitching, perhaps even convulsing - I would still live through it.

So long as its only one CNS depressant in your system, the rule of thumb is that you'll be fine.

A major risk is that there are many over the counter medications, herbs, supplements, and thousands of other things which act as CNS depressants, and can kill a person when they're on an already high dose of a CNS depressant.
Some of these lesser known CNS depressants include things like valerian root in certain kinds of tea, allergy medications (anti-histamines), motion sickness pills (such as dramamine/dimenhydrinate, which is also an antihistamine), blood pressure medications (propranolol, a beta-blocker), and even anti-depressants and anxiolytics like zoloft, effexor, paxil, lexapro, yadda yadda yadda have affinity as an H-1 antagonist and cause sedations.

That's how a lot of celebrities die; they get prescribed so much shit and none of their doctors are really keeping an eye on it, and before they know it they've got 7-8 CNS depressants in their system, have a couple drinks, then pass out and die

alternatively you stop breathing and you die

how CNS depressants kill you during an overdose is by lowering your respiratory rate down to the point that it simply stops -- and this means you also have to be unconscious (i.e., have fallen asleep or passed out).
A single CNS depressant by itself will not do this typically, because the rest of the neurological pathways in your brain not affected by the drug will still be functioning enough to keep up respiratory rate. However, when CNS depressants are mixed (more than one type of CNS depressant is taken), more areas of the brain have their activity inhibited, and the level of sedation compounds.

i would pop a gram of oxycodone right in front of you with confidence that it wouldn't kill me. Although, it would give me a very very bad time, and i'd likely be unconscious within 10 minutes and be shaking/twitching, perhaps even convulsing - I would still live through it.

So long as its only one CNS depressant in your system, the rule of thumb is that you'll be fine.

A major risk is that there are many over the counter medications, herbs, supplements, and thousands of other things which act as CNS depressants, and can kill a person when they're on an already high dose of a CNS depressant.
Some of these lesser known CNS depressants include things like valerian root in certain kinds of tea, allergy medications (anti-histamines), motion sickness pills (such as dramamine/dimenhydrinate, which is also an antihistamine), blood pressure medications (propranolol, a beta-blocker), and even anti-depressants and anxiolytics like zoloft, effexor, paxil, lexapro, yadda yadda yadda have affinity as an H-1 antagonist and cause sedations.

That's how a lot of celebrities die; they get prescribed so much shit and none of their doctors are really keeping an eye on it, and before they know it they've got 7-8 CNS depressants in their system, have a couple drinks, then pass out and die

[Genital Doli]

it is very very difficult to overdose on just an opiate itself (excluding the synthetics like methadone, which sometimes can end up just killing a person for no real reason at all - NMDA antagonism might have something to do with methadone's high toxicity)

opiod overdose is the second leading cause of accidental death you colossal fucking retard

[blumpkin blownuts]

people who stack depressants like that are just flirting with death

which became an incredible thrill for me, once the opiate euphoria was no longer attainable